Search on: PHOSPHODIESTERASE I 
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Descriptor English:   Phosphodiesterase I 
Descriptor Spanish:   Fosfodiesterasa I 
Descriptor Portuguese:   Fosfodiesterase I 
Tree Number:   D08.811.277.352.640.430
Definition English:   A phosphoric diester hydrolase that removes 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated OLIGONUCLEOTIDES. It has low activity towards POLYNUCLEOTIDES and the presence of 3'-phosphate terminus on the substrate may inhibit hydrolysis. 
History Note English:   2004; use PHOSPHODIESTERASE I (NM) 1980-2003 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   38147 
Unique Identifier:   D043264 

Occurrence in VHL:
 

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